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Speaker: Harrison Miller (Alnylam Pharmaceuticals)

Abstract:

Probabilities of success are a key assessment for decision analytic strategy and portfolio models in drug development. Various studies have analyzed historical data using different methodologies and different data sets, but many of these are significantly out of date or are based on limited data sets. This talk will review an attempt to reproduce a landmark paper with a comprehensive, up-to-date data set, and will highlight several key learnings about the nuances, methodologies, data sets, changes over time, and how/when this information can be best leveraged in the context of drug development decision making.